Scientific Publications

Science

Publications and Posters

Belumosudil (KD025) and cGVHD


  • Presentation and Management of cGVHD in Real-World Clinical Practice: A Medical Chart Audit. European Hematology Association. .
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  • Interim Analysis of KD025-213: A Phase 2, Randomized, Multicenter Study to Evaluate the Efficacy and Safety of KD025 in Subjects with Chronic Graft Versus Host Disease (cGVHD) after at Least 2 Prior Lines of Systemic Therapy (The ROCKstar Study). Transplantation and Cellular Therapy Meetings. .
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  • KD025 for Patients with Chronic Graft Versus Host Disease (cGVHD) Long-term Follow-up of a Phase 2a Study (KD025-208). Transplantation and Cellular Therapy Meetings. .
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  • Epidemiology and Real-World Treatment of Chronic Graft-Versus-Host Disease Post Allogeneic Hematopoietic Cell Transplantation (HCT): A U.S. Claims Analysis. ASH Annual Meeting and Exposition. .
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Immuno-oncology: IL-15 Fusion Protein Platform


  • Anti-PD-L1/IL15 fusion protein KD033 demonstrated efficient T cell redirected killing of PD-L1 expressing target cells and in vivo efficacy that correlated to its retention in tumors. American Association of Cancer Research. .
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  • A novel anti-PD1-IL-15 immunocytokine potentiates anti-tumor T cell activity of PD-1 checkpoint blockade and IL-2/15R-beta-gamma agonism. American Association of Cancer Research. .
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  • Anti-PDL1/IL-15 fusion protein increases efficacy-associated rare effector cells in cynomolgus monkey and mouse peripheral blood. European Society for Medical Oncology. .
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  • Synergistic efficacy of anti-PD-L1/IL-15 fusion protein in combination with anti-CTLA-4 antibody in a murine orthotopic 4T1 breast carcinoma model. Society for Immunotherapy of Cancer. .
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ROCK Inhibition


  • Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10. The Journal of Immunology. .
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  • ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings. Sci. Signal. .
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  • Isoform-specific targeting of ROCK proteins in immune cells. Small GTPases. .
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  • Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism. Blood. .
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  • ROCKing cytokine secretion balance in human T cells. Cytokine. .
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  • Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. PNAS. .
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  • Selective ROCK2 inhibition in focal cerebral ischemia. ANA. .
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